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February 6, 2023 | ScienceDirect

Modeling large-volume subcutaneous injection of monoclonal antibodies with anisotropic porohyperelastic models and data-driven tissue layer geometries

Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has become one of the fastest-growing fields in the pharmaceutical industry. The transport and mechanical processes behind large volume injections are poorly understood. Here, we leverage a large-deformation poroelastic model to study high-dose, high-speed subcutaneous injection.
December 6, 2022 | SpringerLink

Anisotropic damage model for collagenous tissues and its application to model fracture and needle insertion mechanics

The analysis of tissue mechanics in biomedical applications demands nonlinear constitutive models able to capture the energy dissipation mechanisms, such as damage, that occur during tissue deformation. Furthermore, implementation of sophisticated material models in finite element models is essential to improve medical devices and diagnostic tools.
March 6, 2022 | ScienceDirect

The Biomechanics of Autoinjector-Skin Interactions During Dynamic Needle Insertion

Autoinjector devices are rapidly becoming the preferred method of drug delivery for a wide array of pharmaceuticals such as monoclonal antibodies. Yet, our understanding of injection biomechanics is limited, but is crucially important to create autoinjectors that lead to the least amount of pain, penetrate the skin to a desired depth, produce small lesions that minimize back flow of drug, and operate robustly even given the variability in the skin mechanics among individuals.
January 6, 2022 | ScienceDirect

Transport and lymphatic uptake of monoclonal antibodies through subcutaneous injection

The subcutaneous injection has emerged to become a feasible self-administration practice for biotherapeutics due to the patient comfort and cost-effectiveness. However, the available knowledge about transport and absorption of these agents after subcutaneous injection is limited. Here, a mathematical framework to study the subcutaneous drug delivery of mAbs from injection to lymphatic uptake is presented.
October 6, 2021 | ScienceDirect

Using poro-elasticity to model the large deformation of tissue during subcutaneous injection

Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has recently attracted unprecedented interests in the pharmaceutical industry. The drug transport in the tissue and mechanical response of the tissue after injection are not yet well-understood. We are motivated to study subcutaneous injection using poro-elasticity, including linear and nonlinear poro-elastic models.