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February 6, 2023 | ScienceDirect

Modeling large-volume subcutaneous injection of monoclonal antibodies with anisotropic porohyperelastic models and data-driven tissue layer geometries

Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has become one of the fastest-growing fields in the pharmaceutical industry. The transport and mechanical processes behind large volume injections are poorly understood. Here, we leverage a large-deformation poroelastic model to study high-dose, high-speed subcutaneous injection.

December 6, 2022 | SpringerLink

Anisotropic damage model for collagenous tissues and its application to model fracture and needle insertion mechanics

The analysis of tissue mechanics in biomedical applications demands nonlinear constitutive models able to capture the energy dissipation mechanisms, such as damage, that occur during tissue deformation. Furthermore, implementation of sophisticated material models in finite element models is essential to improve medical devices and diagnostic tools.

March 6, 2022 | ScienceDirect

The Biomechanics of Autoinjector-Skin Interactions During Dynamic Needle Insertion

Autoinjector devices are rapidly becoming the preferred method of drug delivery for a wide array of pharmaceuticals such as monoclonal antibodies. Yet, our understanding of injection biomechanics is limited, but is crucially important to create autoinjectors that lead to the least amount of pain, penetrate the skin to a desired depth, produce small lesions that minimize back flow of drug, and operate robustly even given the variability in the skin mechanics among individuals.

January 6, 2022 | ScienceDirect

Transport and lymphatic uptake of monoclonal antibodies through subcutaneous injection

The subcutaneous injection has emerged to become a feasible self-administration practice for biotherapeutics due to the patient comfort and cost-effectiveness. However, the available knowledge about transport and absorption of these agents after subcutaneous injection is limited. Here, a mathematical framework to study the subcutaneous drug delivery of mAbs from injection to lymphatic uptake is presented.

October 6, 2021 | ScienceDirect

Using poro-elasticity to model the large deformation of tissue during subcutaneous injection

Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has recently attracted unprecedented interests in the pharmaceutical industry. The drug transport in the tissue and mechanical response of the tissue after injection are not yet well-understood. We are motivated to study subcutaneous injection using poro-elasticity, including linear and nonlinear poro-elastic models.

September 6, 2021 | Wiley Online Library

Wearable glucose monitoring and implantable drug delivery systems for diabetes management

The global cost of diabetes care exceeds $1 trillion each year with more than $327 billion being spent in the United States alone. Despite some of the advances in diabetes care including continuous glucose monitoring systems and insulin pumps, the technology associated with managing diabetes has largely remained unchanged over the past several decades.

July 16, 2021 | ACS Publications

Fluorescence-Detected Mid-Infrared Photothermal Microscopy

We demonstrate instrumentation and methods to enable fluorescence-detected photothermal infrared (F-PTIR) microscopy and then demonstrate the utility of F-PTIR to characterize the composition within phase-separated domains of model amorphous solid dispersions (ASDs) induced by water sorption.

November 6, 2020 | ScienceDirect

A model for a laser-induced cavitation bubble

The complex mechanism behind the laser-induced cavitation bubble has led to challenges in its modeling. Current models can only predict the radius of the single laser-induced cavitation bubble over one or two growth and collapse cycles. To fill the gap, we propose a new model that takes into account the liquid compressibility, heat transfer, and non-equilibrium evaporation and condensation.

June 6, 2020 | Taylor & Francis

Performance characterization of spring actuated autoinjector devices for Emgality and Aimovig

Autoinjectors are a convenient and efficient way to self-administer subcutaneous injections of biopharmaceuticals. Differences in device mechanical design can affect the autoinjector functionality and performance. This study investigates the performance differences of two single-spring-actuated autoinjectors.

April 6, 2020 | Royal Society of Chemistry

Smart Capsule for Non-invasive Sampling and Studying of the Gastrointestinal Microbiome

Gut microbiota plays an important role in host physiology such as obesity, diabetes, and various neurological diseases. Thus, microbiome sampling is a fundamental approach towards better understanding of possible diseases. However, conventional sampling methods, such as endoscopies or colonoscopies, are invasive and cannot reach the entire small intestine.

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